Manus Solis
Metabolic Health
Insulin resistance, metabolic syndrome, and body composition addressed at the physiological root.
Overview
Metabolic syndrome is a cluster of interconnected risk factors: central adiposity, insulin resistance, dyslipidemia, elevated blood pressure, and impaired glucose tolerance. Each factor alone raises cardiovascular and neurodegenerative risk; together, they accelerate biological aging measurably. Roughly one in five Canadian adults meets criteria for metabolic syndrome, and many more carry subclinical insulin resistance that goes undetected by standard fasting glucose screening.
At Manus Solis, we quantify metabolic health with precision. Fasting insulin, HOMA-IR, HbA1c, advanced lipid fractionation, liver enzymes, and inflammatory markers form the Pulsus domain of your Vis Viva Score. We pair these with body composition data, VO2 max, and grip strength from the Virtus domain, and your own reported energy, appetite, and cognitive clarity from the Sensus domain. Treatment is then titrated to response across all three.
Common Symptoms
- Abdominal weight gain
- Difficulty losing weight
- Sugar & carbohydrate cravings
- Fatigue after meals
- Elevated blood pressure
- Brain fog
- Low energy & stamina
- Fatty liver (diagnosed or suspected)
- Elevated triglycerides
- Skin tags
- Dark skin folds (acanthosis nigricans)
- Frequent urination or thirst
What We Measure
- Fasting insulin
- Fasting glucose
- HOMA-IR
- HbA1c
- Advanced lipid panel (LDL-P, ApoB)
- Triglycerides / HDL ratio
- ALT, AST, GGT (liver enzymes)
- hs-CRP
- Uric acid
- Adiponectin
- Fasting leptin
- Thyroid panel
- Testosterone (total & free)
- SHBG
- Vitamin D
Hormones & Treatments
- GLP-1 receptor agonists (semaglutide, tirzepatide)
- Metformin
- Testosterone (when deficient)
- Thyroid hormone (when suboptimal)
- DHEA (selective cases)
- Berberine & targeted nutraceuticals
Custom-compounded by our Ontario pharmacy partner. Individually dosed. Physician-titrated.
Treatment
How We Treat This
Treatment begins with a thorough metabolic assessment and identification of the primary drivers: insulin resistance, hormonal deficiency, hepatic steatosis, or inflammatory load. Dietary and exercise prescriptions are specific, measurable, and individualized. When indicated, we prescribe GLP-1 receptor agonists (semaglutide, tirzepatide) for appetite regulation and glycemic control, metformin for insulin sensitization, and bioidentical hormone optimization where deficiency contributes to metabolic dysfunction. Every intervention is tracked and adjusted through serial bloodwork and functional testing.
Adults with metabolic syndrome, prediabetes, type 2 diabetes, or non-alcoholic fatty liver disease seeking a comprehensive, physician-led protocol. Patients who want to address the root metabolic drivers of weight gain rather than rely on caloric restriction alone. Those interested in GLP-1 therapy under proper medical supervision with ongoing monitoring.
Questions
FAQ
How is insulin resistance diagnosed if my blood sugar is normal?
Fasting glucose is a late marker. Insulin resistance can be present for years before blood sugar rises above the reference range. We measure fasting insulin and calculate HOMA-IR, which detects impaired insulin sensitivity at a much earlier stage. A fasting insulin above 8-10 mIU/L or a HOMA-IR above 2.0 warrants investigation, even when glucose and HbA1c are within the conventional normal range.
Do you prescribe GLP-1 medications like Ozempic or Mounjaro in Ontario?
Yes. When clinically appropriate, we prescribe GLP-1 receptor agonists including semaglutide and tirzepatide as part of a comprehensive metabolic protocol. These medications are prescribed within a structured medical framework that includes baseline and serial bloodwork, body composition tracking, dietary guidance, and regular physician follow-up. We do not prescribe them in isolation or without ongoing monitoring.
What is the connection between low testosterone and metabolic syndrome?
Low testosterone in men is both a consequence and a driver of metabolic syndrome. Visceral adiposity increases aromatase activity, converting testosterone to estradiol and further depleting testosterone levels. This creates a self-reinforcing cycle of insulin resistance, fat accumulation, and hormonal depletion. Testosterone optimization, when combined with metabolic and lifestyle intervention, can help break this cycle and improve insulin sensitivity, body composition, and cardiovascular risk markers.
Can fatty liver disease be reversed?
Non-alcoholic fatty liver disease (NAFLD) is reversible in many cases, particularly when identified early. Reducing hepatic fat requires addressing the underlying insulin resistance. A combination of targeted dietary changes, specific exercise prescriptions, weight reduction, and pharmaceutical support where indicated (metformin, GLP-1 agonists) can normalize liver enzymes and reduce hepatic steatosis within months. We track progress with serial liver enzymes, imaging when appropriate, and metabolic markers.
Ontario-Wide
Virtual consultations available to patients in Toronto, Mississauga, Brampton, Markham, Vaughan, Richmond Hill, Oakville, Burlington, Hamilton, Ottawa, London, and across Ontario. Bloodwork requisitions and prescriptions managed remotely. Compounds shipped directly from our Ontario pharmacy partner.
Begin
Book a Discovery Call
A confidential conversation with our physician and founder.
inquiries@manussolis.com · Yorkville, Toronto